Drug distribution
Objectives:
=> To understand and describe the processes by which drugs are
distributed throughout the body=> To understand the
effect of protein binding on drug distribution and methods by which protein
binding is measured
Drug distribution means the reversible transfer of drug from one location to
another within the body. Once a drug has entered the vascular system it becomes
distributed throughout the various tissues and body fluids in a pattern that
reflects the physiochemical nature of the drug and the ease with which it
penetrates different membranes. The ONE COMPARTMENT model assumes rapid
distribution but it does not preclude extensive distribution into various
tissues.
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