One compartment I.V. bolus
Objectives:
=> To understand the assumptions associated with the one compartment
model
=> To understand the properties of first order kinetics and linear models
=> To write the differential equations for a simple pharmacokinetic model
=> To recognize and use the integrated equations for a one compartment
linear model
=> To define, use, and calculate the parameters, kel, t1/2, V,
and AUC as they apply to a one compartment linear model
Definition: Pharmacokinetics is the study of drug and/or metabolite
kinetics in the body. It deals with a mathematical description of the rates
of drug movement into, within and exit from the body. It also includes the study
of drug metabolism or biotransformation rates. The body is a very complex system
and a drug undergoes many steps as it is being absorbed, distributed
through the body, metabolized or excreted (ADME).
Diagram IV-1, Drug Disposition
The drug also interacts with receptors and causes therapeutic and/or toxic
responses. Although the details of drug kinetics are complicated it is fortunate
that we can often approximate drug kinetic processes using "simple" mathematical
models.
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