Intravenous Infusion
Objectives:
=> To draw the scheme and write the differential equations for a one
compartment pharmacokinetic model after IV. infusion administration
=> To recognize and use the integrated equation for drug
concentrations during and after an IV. infusion administration
=> To calculate kel and V from IV. infusion data
=> To design and calculate appropriate IV. infusion (IV. infusion
alone, fast/slow IV. infusion, or infusion/bolus) dosage regimens
Commonly in a hospital setting a patient will receive a drug by intravenous
infusion. The inconvenience of administering the drug over a long time is not a
real problem with bedridden patients. Some may already be receiving intravenous
fluids. If a drug is chemically stable and is compatible with the intravenous
fluid it may be added to the fluid and thereby be given by slow infusion.
Some drugs cannot be given by rapid intravenous injection. Therefore they may
be given by slower IV infusion over 15 or 30 minutes.
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